1α,25-Dihydroxyvitamin D3-3β-bromoacetate, a potential cancer therapeutic agent: Synthesis and molecular mechanism of action
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چکیده
منابع مشابه
Phosphorylation of the 1,25-dihydroxyvitamin D3 receptor. A primary event in 1,25-dihydroxyvitamin D3 action.
1,25-Dihydroxyvitamin D3 is believed to mediate the regulation of calcium metabolism by a steroid hormone receptor mechanism. We now demonstrate that phosphorylation of the 1,25-dihydroxyvitamin D3 receptor occurs rapidly in embryonic chick duodenal organ culture in response to 1,25-dihydroxyvitamin D3. Phosphorylation of the receptor is strongly induced within 1 h by 1,25-dihydroxyvitamin D3 a...
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We have investigated the molecular mechanism whereby 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] inhibits adipogenesis in vitro. 1,25(OH)2D3 blocks 3T3-L1 cell differentiation into adipocytes in a dose-dependent manner; however, the inhibition is ineffective 24-48 h after the differentiation is initiated, suggesting that 1,25(OH)2D3 inhibits only the early events of the adipogenic program. Treatment...
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Receptors for 1,25-dihydroxyvitamin D3 have been shown to exist in cultured breast cancer cells and in primary breast cancers. It is reported here that 1,25-dihydroxyvitamin D3 receptor (1,25-DR) was present in 80% of 54 unselected breast cancers. The concentration of 1,25-DR in the 43 receptor-positive tumors was 1.9 +/- 0.4 fmol/mg protein (S.E.). There was no correlation between 1,25-DR pres...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2011
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2011.02.025